https://optibrium.com/project/docking-and-alignment/ 2024-05-15T10:48:02Z https://cdn-thumbnails.sproutvideo.com/e89adcb71b1ae0ce60/d1c6b06caa027af4/0/w_1280/poster.jpg?v=1715788082 Pose Generation Interface A demo of StarDrop's Pose Generation Interface that provides a universal link with platforms for 3D compound docking and alignment. This enables enables users to seamlessly run expertly prepared 3D docking and alignment models and evaluate multiple iterations of designs, in combination with StarDrop’s capabilities for data visualisation, 2D SAR analyses and predictive modelling. 167 https://videos.sproutvideo.com/embed/e89adcb71b1ae0ce60/d1c6b06caa027af4 2018-01-02T11:17:34Z StarDrop Modules and Features https://optibrium.com/videos/introduction-to-p450-module/ 2023-01-31T09:41:04Z https://cdn-thumbnails.sproutvideo.com/1c9adcb71417e9c494/66ec492a79d009ba/0/w_1152/poster.jpg?v=1675179664 Introduction to P450 Module This short movie gives an introduction to StarDrop's P450 metabolism module which enables you to quickly identify the regions of your molecules that are most vulnerable to metabolism by the major drug metabolising isoforms of cytochrome P450. 120 https://videos.sproutvideo.com/embed/1c9adcb71417e9c494/66ec492a79d009ba 2018-01-04T05:21:15Z StarDrop Modules and Features https://optibrium.com/videos/building-a-qsar-model/ 2024-05-15T10:24:27Z https://cdn-thumbnails.sproutvideo.com/1c9adcb61c1becc494/0d5d6fcb966761e9/3/w_1280/poster.jpg?v=1715786667 Building a QSAR Model In this demo we use the Auto-Modeller to build a QSAR model of some measured data for target affinity. Using this new model we guide the design of a new compound using probabilistic scoring to consider the relative importance of potency alongside ADME properties and then the Glowing Molecule to help modify the existing compound to improve its overall balance of properties. 372 https://videos.sproutvideo.com/embed/1c9adcb61c1becc494/0d5d6fcb966761e9 2018-01-05T05:53:25Z StarDrop Modules and Features https://optibrium.com/videos/flexible-substructure-searching/ 2024-05-15T10:56:41Z https://cdn-thumbnails.sproutvideo.com/a09adcb61c14e3cf28/29fde1617b5e9507/3/w_1280/poster.jpg?v=1715788601 Flexible Substructure Searching This short video illustrates how to perform flexible substructure searches, including variable atoms, bonds and linkers using StarDrop's Find tool. 138 https://videos.sproutvideo.com/embed/a09adcb61c14e3cf28/29fde1617b5e9507 2018-01-05T07:07:37Z StarDrop Hints and Tips https://optibrium.com/videos/information-rich-sar-plots/ 2023-02-03T09:47:47Z https://cdn-thumbnails.sproutvideo.com/1c9adcb61c15e9cf94/e27f351f83d91399/3/w_1198/poster.jpg?v=1675439267 Information Rich SAR Visualisation This short movie illustrates how to create information-rich SAR plots, including pie charts, histograms or radar plots to view property distributions by R-group in StarDrop's data visualisation tab. 83 https://videos.sproutvideo.com/embed/1c9adcb61c15e9cf94/e27f351f83d91399 2018-01-05T07:38:35Z StarDrop Hints and Tips https://optibrium.com/videos/matched-molecular-pair-analysis/ 2024-05-15T11:00:46Z https://cdn-thumbnails.sproutvideo.com/7c9adcb61c15e8c6f4/f6941608b41dd92b/0/w_1280/poster.jpg?v=1715788846 Matched Molecular Pair Analysis This short video gives an introduction to the Matched Molecular Pair Analysis tool in StarDrop and how you can interact with the results in Card View. If you are interested in Matched Molecular Pair Analysis, you may also like to see the tutorial on Matched Series Analysis, which goes beyond matched pairs by considering longer series of matched compound to make more relevant suggestions for substitutions in your chemical series. 213 https://videos.sproutvideo.com/embed/7c9adcb61c15e8c6f4/f6941608b41dd92b 2018-01-05T07:39:07Z StarDrop Hints and Tips https://optibrium.com/videos/activity-neighbourhoods/ 2024-05-15T10:59:04Z https://cdn-thumbnails.sproutvideo.com/a09adcb61c15e8c528/86983d099564c0db/2/w_1280/poster.jpg?v=1715788744 Activity Neighbourhood Analysis This short video gives an introduction to the Activity Neighbourhood analysis tool in StarDrop's Card View. 137 https://videos.sproutvideo.com/embed/a09adcb61c15e8c528/86983d099564c0db 2018-01-05T07:39:25Z StarDrop Hints and Tips https://optibrium.com/project/glowing-molecule/ 2024-05-15T10:57:10Z https://cdn-thumbnails.sproutvideo.com/e89adcb61c15e8cf60/2efc1ef3652a9b11/1/w_1280/poster.jpg?v=1715788630 Glowing Molecule StarDrop's Glowing Molecule brings model predictions to life, showing you which parts of a molecule are having the biggest impact on its predicted properties. This quick introduction shows you how... 55 https://videos.sproutvideo.com/embed/e89adcb61c15e8cf60/2efc1ef3652a9b11 2018-01-05T07:40:24Z StarDrop Hints and Tips https://optibrium.com/videos/clustering-2/ 2023-02-03T09:50:10Z https://cdn-thumbnails.sproutvideo.com/a09adcb61c15efc228/e09077fd74d63155/3/w_1280/poster.jpg?v=1675439410 Clustering The clustering tool makes it easy to identify groups of similar compounds within a dataset based on either their structure or properties. This demo shows how the cluster information can be used with StarDrop's chemical space and data visualisation to easily compare chemical series within a library and target the highest quality chemistries. 137 https://videos.sproutvideo.com/embed/a09adcb61c15efc228/e09077fd74d63155 2018-01-05T07:41:16Z StarDrop Hints and Tips https://optibrium.com/tutorials/automatic-generation-of-new-compound-ideas/ 2024-05-15T10:41:04Z https://cdn-thumbnails.sproutvideo.com/1c9adcb61d1fe8c594/e040952c92384ef1/3/w_1280/poster.jpg?v=1715787664 Tutorial: Automatic Generation of New Compound Ideas The objective in this tutorial is to evolve the chemistry around three lead compounds which have good ADME properties but which have insufficient inhibition of the target, the Serotonin transporter. Using Nova and Probabilistic Scoring we look at how we can generate new ideas for compounds to improve the potency while maintaining the balance of other properties. 518 https://videos.sproutvideo.com/embed/1c9adcb61d1fe8c594/e040952c92384ef1 2018-01-05T10:25:18Z StarDrop Tutorials https://optibrium.com/project/adme-qsar/ 2023-04-06T09:19:58Z https://cdn-thumbnails.sproutvideo.com/1c9adeb01819e4ce94/dc32475a4e0d781d/3/w_514/poster.jpg?v=1680790798 StarDrop - Auto-Modeller This video showcases the use of the Auto-Modeller to construct a QSAR model for target affinity based on measured data. The resulting model is then utilized to aid in the creation of a new compound, using probabilistic scoring to balance potency and ADME properties. Additionally, the Glowing Molecule tool is employed to modify an existing compound and enhance its overall properties. 371 https://videos.sproutvideo.com/embed/1c9adeb01819e4ce94/dc32475a4e0d781d 2018-04-23T06:19:04Z StarDrop Modules and Features ADME https://optibrium.com/videos/introduction-to-stardrop/ 2023-04-06T08:17:17Z https://cdn-thumbnails.sproutvideo.com/a49adeb41e1feaca2c/3a3c400cb78553cc/0/w_1280/poster.jpg?v=1680787037 Introduction to StarDrop With its comprehensive suite of integrated software, StarDrop delivers best-in-class in silico technologies within a highly visual and user-friendly interface. StarDrop enables a seamless flow from the latest data through predictive modelling to decision-making regarding the next round of synthesis and research, improving the speed, efficiency, and productivity of the discovery process. Learn more at: www.optibrium.com/stardrop 166 https://videos.sproutvideo.com/embed/a49adeb41e1feaca2c/3a3c400cb78553cc 2018-05-18T04:30:38Z StarDrop Modules and Features https://optibrium.com/videos/data-visualisation-introduction/ 2023-02-03T09:37:42Z https://cdn-thumbnails.sproutvideo.com/709adebb1219e4c0f8/1849e6d9d5a03903/2/w_1280/poster.jpg?v=1675438662 Modules and Features: Data Visualisation 6.5 This short video gives an overview of StarDrop’s rich data visualisation capabilities. The videos in the following series introduce how to quickly produce publication-quality charts and interactively explore your data. 80 https://videos.sproutvideo.com/embed/709adebb1219e4c0f8/1849e6d9d5a03903 2018-05-23T10:16:01Z StarDrop Modules and Features https://optibrium.com/videos/r-group-analysis-2/ 2023-03-27T06:49:08Z https://cdn-thumbnails.sproutvideo.com/1c9adebb101beec594/4e388ca27713ae3c/2/w_1280/poster.jpg?v=1679917748 Hints and Tips: R-group Analysis StarDrop's R-group analysis makes it quick and easy to explore the variation of properties by the substituents within a chemical series. This video shows how to perform an R-group decomposition and create SAR plots. The next video in this short series, illustrates how to create information-rich SAR plots. 147 https://videos.sproutvideo.com/embed/1c9adebb101beec594/4e388ca27713ae3c 2018-05-24T02:12:01Z StarDrop Hints and Tips https://optibrium.com/project/seesar/ 2024-05-15T10:13:06Z https://cdn-thumbnails.sproutvideo.com/e89dd8b41d1ae6ce60/8decfcf605b6df0d/0/w_1280/poster.jpg?v=1715785986 Modules and Features: SeeSAR View This short movie gives an introduction to StarDrop's SeeSAR View module, that enables you to visualise your ligands in their protein environment and identify the key interactions driving binding affinity in 3D. These structures can be derived from X-ray crystallography or predicted with any docking software.. 136 https://videos.sproutvideo.com/embed/e89dd8b41d1ae6ce60/8decfcf605b6df0d 2019-10-18T10:22:07Z StarDrop Modules and Features https://optibrium.com/events/webinars/multi-parameter-optimisation-in-practice/? 2023-04-06T09:15:02Z https://cdn-thumbnails.sproutvideo.com/709cd6ba1d19e6c0f9/8532eaf35b9cef64/2/w_1280/poster.jpg?v=1680790502 Multi-parameter Optimisation in Practice A safe and efficacious drug must possess a balance of potency with appropriate ADME and toxicity properties. The ideal property profile will be different for every project, depending on the therapeutic indication, intended route of administration and commercial factors; the goal of a drug discovery project is to target compounds that are likely to achieve this delicate balance as quickly as possible. 3397 https://videos.sproutvideo.com/embed/709cd6ba1d19e6c0f9/8532eaf35b9cef64 2020-09-09T08:17:05Z https://optibrium.com/tutorials/reaction-based-library-enumeration-3/ 2024-05-15T10:39:34Z https://cdn-thumbnails.sproutvideo.com/069ddeb11a11eac78f/8734b6ba9fcd167b/1688386476/w_1280/poster.jpg?v=1715787574 Reaction-based Library Enumeration Reaction-based enumeration method offers you a user-friendly, flexible workflow for virtual library design, starting from a reaction you like to apply to your chosen set of reagents. The method is part of StarDrop’s Nova module, complementing the compound idea generation methods based on chemistry transformations and matched series analysis, along with scaffold-based library enumeration for virtual library design. 459 https://videos.sproutvideo.com/embed/069ddeb11a11eac78f/8734b6ba9fcd167b 2021-01-19T07:55:37Z StarDrop Modules and Features StarDrop Tutorials https://optibrium.com/cerella/ 2023-04-06T08:22:31Z https://cdn-thumbnails.sproutvideo.com/119ddcb31b1fe2cb98/47f2386b4697e3e6/0/w_1280/poster.jpg?v=1680787351 Cerella introduction.mp4 Cerella™ employs a cutting-edge deep learning technique to address challenges in drug discovery data, enhancing efficiency and reducing costs. By identifying high-quality compounds with confidence, Cerella uncovers hidden opportunities arising from missing, uncertain, or inaccurate data and prioritizes the most valuable experiments. From early hit analysis to preclinical candidate selection, Cerella delivers exceptional results, tailored for enterprise deployment and seamless integration with experimentalists' workflows. 180 https://videos.sproutvideo.com/embed/119ddcb31b1fe2cb98/47f2386b4697e3e6 2021-04-21T08:09:22Z Cerella https://optibrium.com/cerella/ 2023-04-04T10:29:16Z https://cdn-thumbnails.sproutvideo.com/709ddab51c1feac9f9/537b191332f2fbcb/0/w_1280/poster.jpg?v=1680622156 Scalable & Secure section.mp4 Scalable & Secure section.mp4 165 https://videos.sproutvideo.com/embed/709ddab51c1feac9f9/537b191332f2fbcb 2021-07-12T07:47:44Z https://optibrium.com/events/webinars/3d-ligand-based-drug-design-webinar/ 2023-01-31T11:39:11Z https://cdn-thumbnails.sproutvideo.com/4d9dd9ba1418e8c9c4/82291214e674ec53/1631710495/w_1280/poster.jpg?v=1675186751 3D Ligand-based drug design.mp4 In this webinar, we demonstrate intuitive workflows for 3D ligand-based drug design, allowing you to; • Enable 3D design, even with little or no target structure information • Find novel active compounds with 3D virtual screening against known actives • Understand 3D SAR with industry-leading pose prediction • Generate binding mode hypotheses by alignment of multiple known actives • Complement structure-based design approaches with a ligand-centred perspective 3410 https://videos.sproutvideo.com/embed/4d9dd9ba1418e8c9c4/82291214e674ec53 2021-09-15T07:16:24Z https://optibrium.com/events/webinars/ai-in-early-drug-discovery-from-promise-to-practice/ 2023-01-30T12:46:17Z https://cdn-thumbnails.sproutvideo.com/4d9edfb21a1ae7c7c4/7448f172e9755a04/1/w_1280/poster.jpg?v=1675104377 AI in early drug discovery.mp4 This panel discuss the state of AI in early drug discovery from hit to preclinical candidate and share their experiences with and expectations of AI, including predictive modelling, synthesis prediction and generative chemistry. Hear about the successes of AI and an outlook on what AI needs to achieve to really transform drug discovery. 3334 https://videos.sproutvideo.com/embed/4d9edfb21a1ae7c7c4/7448f172e9755a04 2022-05-19T05:30:40Z Cerella AI in Drug Discovery Presentations and Webinars https://optibrium.com/events/webinar/predict-pk-from-limited-adme-data-with-deep-learning/ 2023-02-10T07:34:31Z https://cdn-thumbnails.sproutvideo.com/ea9fdfbe141ee5c163/fcf1711a77957be9/3/w_1280/poster.jpg?v=1676036071 Predicting Pharmacokinetics A real-world case study where we applied deep learning to guide a project, in which potential compounds were displaying good activity profiles but the team wanted to improve their PK profile to achieve better efficacy. Find out more about: • The challenges we face in using data in drug discovery • What deep learning imputation is, and how it works in the context of PK • Real-life case studies of deep learning in action for PK prediction, and how our collaborators have found success using these methods • Optibrium’s Cerella™ AI drug discovery software 3122 https://videos.sproutvideo.com/embed/ea9fdfbe141ee5c163/fcf1711a77957be9 2023-02-10T07:14:19Z https://optibrium.com/events/webinars/overcoming-challenges-in-drug-metabolism-in-silico-approaches/ 2024-04-17T09:39:21Z https://cdn-thumbnails.sproutvideo.com/4490d4b21b15e3c5cd/70f75c380176f297/1710348546/w_1280/poster.jpg?v=1713364761 Overcoming challenges in drug metabolism: in silico approaches Interpreting metabolite-ID experiments; determining the right species for animal studies; providing optimisation suggestions for your medicinal chemistry colleagues to overcome metabolism issues – these are just a few of the challenging tasks assigned to DMPK scientists. How can we best tackle these to ensure the success of our drug discovery projects? Watch Optibrium CEO, Dr Matthew Segall, as he explores Optibrium’s extensive metabolism prediction research, and demonstrates how in silico modelling techniques can support DMPK scientists in their workflows. The webinar covers: 1) The drug metabolism challenges that might be faced by DMPK scientists 2) The application of in silico modelling methods to target these challenges, including state-of-the-art quantum mechanical and machine learning models 3) A demonstration of our latest software, Semeta™ , an in silico metabolism prediction platform tailored specifically for DMPK scientists If you'd like to learn more about about how you can use StarDrop or Semeta to help your drug discovery projects or request a trial, please visit our website: https://bit.ly/3NxUh2l 3206 https://videos.sproutvideo.com/embed/4490d4b21b15e3c5cd/70f75c380176f297 2024-03-13T11:12:04Z https://optibrium.com/events/webinars/how-to-run-a-successful-drug-discovery-team/ 2024-06-06T05:16:00Z https://cdn-thumbnails.sproutvideo.com/4490d5b11e1ae5cbcd/4f200ec69d31cdda/0/w_1280/poster.jpg?v=1717668960 How to run a successful drug discovery team How to run a successful drug discovery team 3518 https://videos.sproutvideo.com/embed/4490d5b11e1ae5cbcd/4f200ec69d31cdda 2024-04-17T08:56:15Z https://optibrium.com/webinars/an-augmented-approach-to-generative-chemistry/ 2024-06-28T09:47:11Z https://cdn-thumbnails.sproutvideo.com/0690dbb81a1ae6c18f/9fa58ae7e68ac9af/0/w_1280/poster.jpg?v=1719586031 An augmented approach to generative chemistry Generative molecular design provides new exciting avenues of chemical space exploration. But how can we use these methods effectively to assess many optimisation strategies and find the compounds destined for success in our projects? In this webinar, Dr Matt Segall and Dr Michael Parker explore state-of-the-art generative chemistry and discuss the importance of an augmented intelligence approach for successful discovery. They discuss: The essential criteria that any algorithms must hit for successful generative chemistry How augmented intelligence approaches are maximising the effectiveness of generative chemistry A demo of Optibrium’s StarDrop Nova and Inspyra platforms for generating new compound ideas Optibrium’s latest research into new AI generative chemistry methodologies 3333 https://videos.sproutvideo.com/embed/0690dbb81a1ae6c18f/9fa58ae7e68ac9af 2024-06-28T08:10:27Z https://optibrium.com/webinars/finding-balance-in-drug-discovery-through-multi-parameter-optimisation/ 2024-07-25T09:28:44Z https://cdn-thumbnails.sproutvideo.com/1191d3b61e1be0ce98/2c54aed58a1e7f1e/0/w_1280/poster.jpg?v=1721917724 Finding balance in drug discovery through multi-parameter optimisation Successful drugs require a delicate balance of many properties, such as potency, ADME and toxicity, to meet a project’s therapeutic objective. To make decisions about compound progression and assay selection, the available data must be assessed against project-specific criteria. However, the data on which we base our decisions often come from different sources and can vary in quality, so how can we use this information to make confident decisions? In addition, how can we be sure that the criteria we’re using are the most appropriate? In this webinar, Optibrium’s Chief Scientific Officer Edmund Champness explores the art of multi-parameter optimisation (MPO). He’ll cover: Key considerations for effective multi-parameter optimisation Using historical data to help us choose the right criteria for our projects The answers to your MPO questions in an interactive Q&A session 3665 https://videos.sproutvideo.com/embed/1191d3b61e1be0ce98/2c54aed58a1e7f1e 2024-07-25T04:56:11Z https://optibrium.com/webinars/upcoming-the-complexity-of-collaboration-in-drug-discovery/ 2024-09-20T04:42:48Z https://cdn-thumbnails.sproutvideo.com/1191d2bc1218e3c998/34aa805b5ad97323/0/w_1280/poster.jpg?v=1726825368 The complexity of collaboration in drug discovery Everyone knows smooth collaboration can speed up successful drug discovery projects. But how can we collaborate easily in drug discovery teams, where many specialists must join forces to generate and analyse lots of different data, in complex multi-step processes? 3319 https://videos.sproutvideo.com/embed/1191d2bc1218e3c998/34aa805b5ad97323 2024-09-18T05:11:34Z